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  "Author": "Na You <youn@mail.sysu.edu.cn> and Gongyi Huang<53hgy@163.com>",
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  "Description": "Genotyping the population using next generation sequencing\ndata is essentially important for the rare variant detection.\nIn order to distinguish the genomic structural variation from\nsequencing error, we propose a statistical model which involves\nthe genotype effect through a latent variable to depict the\ndistribution of non-reference allele frequency data among\ndifferent samples and different genome loci, while decomposing\nthe sequencing error into sample effect and positional effect.\nAn ECM algorithm is implemented to estimate the model\nparameters, and then the genotypes and SNPs are inferred based\non the empirical Bayes method.",
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